We combine univariate and multivariate analyses of fMRI data from a large cohort of cognitively normal older adults (N=100) to measure hippocampal activity and cortical reinstatement during retrieval of trial-unique associations. Yet, the degree to which this mechanism is impaired with age, and contributes to variability in episodic memory, remains unclear. Hippocampal pattern completion is a fundamental process supporting episodic memory. Summary of regression analyses examining the relationship between hippocampal subfield activity during associative retrieval (associative hit - CR) and associative memory.Īge-related episodic memory decline is characterized by striking heterogeneity across individuals. Summary of hierarchical regression analysis predicting associative d’. Analysis of head motion and its effects on key dependent variables of interest. Summary of linear mixed effects models examining effects of stimulus category (face, place) on relationships between hippocampal activity and cortical reinstatement. Summary of linear and logistic mixed effects models examining effects of stimulus category (face, place) on relationships between neural variables and behavioural variables. Summary of linear and logistic mixed effects model results when item miss trials are excluded. Summary of model parameters for mixed effects models.
#Context reinstatement encoding specificity principle trial#
Reaction time (ms) and trial counts as a function of trial type.
Neuropsychological test battery performance. Supplementary file 1: Supplementary tables.
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